Science / Technology
Vaxxel R&D program to address the global need in vaccine against pneumoviruses is based on two proprietary technologies :
Metavac® Vaccine platform
From its expertise in virology, Vaxxel developed a proprietary live-attenuated viral platform based on an engineered recombinant HMPV strain. This proprietary Metavac® platform is versatile by modifying its genome in order to express additional viral antigens of interest, such as the F antigen of HRSV.
Vaxxel acquired from Transgene the DuckCelt®-T17 avian cell line, permissive to several viruses, including pneumoviruses and producing high yields of Metavac®-based vaccine candidates, while preserving its immunogenic properties. This cell line growing in suspension and serum-free conditions presents suitable characteristics for industrial scalable production in bioreactor.
Avian Cell Line DuckCelt®-T17 Is an Efficient Production System for Live-Attenuated Human Metapneumovirus Vaccine Candidate Metavac®
Chupin C, Pizzorno A, Traversier A, Brun P, Ogonczyk-Makowska D, Padey B, Milesi C, Dulière V, Laurent E, Julien T, Galloux M, Lina B, Eléouët J-F, Moreau K, Hamelin M-E, Terrier O, Boivin G, Dubois J, Rosa-Calatrava M. Vaccines — October 2021
Strain-Dependent Impact of G and SH Deletions Provide New Insights for Live-Attenuated HMPV Vaccine Development.
Dubois J, Pizzorno A, Cavanagh M-H, Padey B, Nicolas de Lamballerie C, Uyar O, Venable M-C, Carbonneau J, Traversier A, Julien T, Lavigne S, Couture C, Lina B, Hamelin M-E, Terrier O, Rosa-Calatrava M, Boivin G. Vaccines — October 2019
Human Metapneumovirus Activates NOD-like Receptor Protein 3 Inflammasome via Its Small Hydrophobic Protein Which Plays a Detrimental Role during Infection in Mice.
Lê V.B, Dubois J, Couture C, Cavanagh M-H, Uyar O, Pizzorno A, Rosa-Calatrava M, Hamelin M-E, Boivin G. PLoS Pathog. — April 2019
Influenza viruses production: Evaluation of a novel avian cell line DuckCelt®-T17.
Emma Petiot, Anaïs Proust, Aurélien Traversier, Laurent Durous, Frédéric Dappozze, Marianne Gras, Chantal Guillard, Jean-Marc Balloul, Manuel Rosa-Calatrava. Vaccine. — May 2018
Mutations in the fusion protein heptad repeat domains of human metapneumovirus impact on the formation of syncytia.
Dubois J, Cavanagh M-H, Terrier O, Hamelin M-E, Lina B, Shi R, Rosa-Calatrava M, Boivin G. J Gen Virol. — June 2017
Effect of in vitro syncytium formation on the severity of human metapneumovirus disease in a murine model.
Aerts L, Cavanagh MH, Dubois J, Carbonneau J, Rhéaume C, Lavigne S, Couture C, Hamelin MÈ, Boivin G. PLoS One. — March 2015
Recent developments with live-attenuated recombinant paramyxovirus vaccines.
Jean-Christophe Le Bayon, Bruno Lina, Manuel Rosa-Calatrava, Guy Boivin. Rev Med Virol. — January 2013